Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 6th World Congress on Hypertension and Public Health Paris, France.

Day 2 :

Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Remigijus Žaliūnas photo
Biography:

Remigijus ŽaliÅ«nas is an Academician, Professor, Habilitated Doctor (biomedical sciences, medicine), Full Member of the Lithuanian Academy of Sciences, Rector of the Lithuanian University of Health Sciences, Head of the Department of Cardiology at the Medical Academy of the Lithuanian University of Health Sciences, Chairman of the Kaunas Region Society of Cardiology, President of the Lithuanian Tennis Union of Physicians, Member of the Executive Committee of the Lithuanian Student Basketball League, Member of Kaunas City Council of Academic Affairs, Member of the Board of the Association Santaka Valley, Doctor Honoris Causa of Moldova State University of Medicine and Pharmacy “Nicolae Testemitanu”, and an Honorary Consul of France in Kaunas. He has defended his Doctoral thesis in 1990 and his Habilitation thesis in 1995. In 1996, he was awarded the degree of an Associate Professor, and in 1999, the degree of a Professor. He is the author of 266 scientific publications, co-author of eight textbooks and seven teaching books.

 

 

Abstract:

Clinical and teaching activities of the Cardiology Department of the Lithuanian University of Health Sciences are inter-related with extensive scientific research. Scientific studies include joint research projects with other scientific – Research or Clinical Departments of the Lithuanian University of Health Sciences, such as Molecular Genetic laboratory, Epidemiologic laboratory, Ophthalmology and Radiology Departments, etc. Epidemiologic genetic studies include evaluation of the frequency of allele variants, investigations of 5A allele and its impact on the remodeling of ischemic myocardium. Genetic studies are focused on the analysis of the impact of SCARB1 single nucleotide polymorphism (SNP) rs5888 with plasma lipid profile and association with CAD in Lithuanian population characterized by high morbidity and mortality from CAD, on the search of molecular biomarkers to identify patients at risk for sporadic ascending aortic aneurysm and aortic dissection and on pharmacogenomics of anticoagulants and antiplatelets. A prospective cohort study is carried out for evaluation of links between cardio-vascular changes and genetic, metabolic and lifestyle cardiovascular risk factors in middle-aged individuals. MRI and echocardiographic studies include evaluation of left ventricular mechanics in functional ischemic mitral regurgitation in acute inferior myocardial infarction, comparison of dobutamine stress speckle tracking echocardiography and adenosine stress MRI in assessing significant coronary artery stenosis in patients with moderate and high probability of CAD, search of predictors of positive response to cardiac resynchronization therapy, evaluation of MRI feasibility to determine myocardial scar transmurality using the functional parameters alone. Two big studies are carried out in collaboration with foreign partners: “A clinical trial for the assessment of safety and efficacy of the laser wire ablation for the interventional treatment of paroxysmal atrial fibrillation. A first in human feasibility trial” and FP7-HEALTH-2013-INOVATION project “DISCHARGE – Diagnostic imaging strategies for patients with stable chest pain and intermediate risk of coronary artery disease: comparative effectiveness research of existing technologies”.

 

Keynote Forum

Yochai Birnbaum & Yumei Ye

Baylor College of Medicine, USA & University of Texas Medical Branch, USA

Keynote: SGLT-2 inhibitors and the heart: Mechanisms of protection
Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Yochai Birnbaum & Yumei Ye photo
Biography:

Author 1:

Yochai Birnbaum has completed his MD from the Hebrew University of Jerusalem, Israel. He is the John S Dunn Chair, Professor of Medicine at Baylor College of Medicine, Houston, Texas, USA. He has published more than 320 papers in reputed journals and has been serving as an Editorial Board Member of six journals.

 

Author 2:                                                

Yumei Ye has completed her MD at the age of 24 years from Nanjing University of Traditional Chinese Medicine, Nanjing China. She is an Associate Professor at The Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas. She has published more than 40 papers in reputed journals.           

 

 

Abstract:

We assessed whether the SGLT-2 inhibitor dapagliflozin (Dapa) attenuates the upregulation of the cardiac Na+/H+ exchanger (NHE-1) in-vitro in mouse cardiofibroblasts stimulated with lipopolysaccharides (LPS) and whether this effect is dependent on adenosine monophosphate kinase (AMPK) activation. Mouse cardiofibroblasts were exposed for 16 hours to Dapa (0.4 μM), AMPK activator [A769662 (10 μM)], AMPK inhibitor [compound C (CC) (10 μM), an SGLT1 and SGLT2 inhibitor [phlorizin (PZ) (100 μM)], Dapa+CC, or Dapa+PZ, and then stimulated with LPS (10 ng/ml) for three hours. NHE-1 mRNA levels were assessed by rt-PCR and total AMPK, phosphorylated-AMPK (P-AMPK), NHE-1 and heat shock protein-70 (Hsp70) protein levels in the whole cell lysate by immunoblotting. In addition, NHE-1 protein levels attached to Hsp70 were assessed by immunoprecipitation. Exposure to LPS significantly reduced P-AMPK levels in the cardiofibroblasts. A769662 and Dapa equally increased P-AMPK. The effect was blocked by CC. Phlorizin had no effect on P-AMPK. LPS exposure significantly increased NHE-1 mRNA levels. Both Dapa and A769662 equally attenuated this increase. The effect of Dapa was blocked with CC. Interestingly, none of the compounds significantly affected NHE-1 and Hsp70 protein levels in the whole cell lysate. However, LPS significantly increased the concentration of NHE-1 attached to Hsp70. Both Dapa and A769662 attenuated this association and CC blocked the effect of Dapa. Again, phlorizin had no effect and did not alter the effect of Dapa. Dapa increases P-AMPK in cardiofibroblasts exposed to LPS. Dapa attenuated the increase in NHE-1 mRNA and the association between NHE-1 and Hsp70. This effect was dependent on AMPK.

 

  • Cardiovascular Diseases | Healthcare & Technologies | Cardiac Diagnostic Tests | Device Therapy | Clinical Cases In Cardiology | Hypertension & Cardiology | Cardiovascular Risk Assessment |
Location: Paris, France
Speaker

Chair

Ehud Baron

X-Cardio Corp. KK, Japan

Session Introduction

Shashi Mawar

All India Institute of Medical Sciences, India

Title: Home based management of Hypertension among elderly: Indian scenario

Time : 10:50-11:15

Speaker
Biography:

Shashi Mawar has total experience of 18 years in various positions. Presently she is working as a Lecturer at college of Nursing, AIIMS New Delhi. She is a lifetime member of Trained Nurses Association of India, Nursing Research Society of India, Indian Association of Neonatal Nurses and Indian Association of Preventive and social medicine. She participated as co-ordinator, Panelist, and Resource person at various National and International forums. She is a master trainer for Global Funded project for Aids, Tuberculosis and Malaria- AIDS and Tuberculosis, Advanced trauma care for Nurses etc. She has some national and international publications and paper presentations.

Abstract:

Numerous studies have identified effective evidence based strategies in the control of high blood pressure used by nurses. Good quality studies demonstrated that, use of treatment algorithms, nurse prescribing, community monitoring are effective evidence based strategies that significantly reduced both systolic and diastolic blood pressure (Clark et al., 2010; Denver et al., 2003; Kotseva et al., 2010).

Numerous studies demonstrated that nurses’ role in patient education significantly improved patients’ health lifestyle behaviors, medication adherence self-efficacy, and reduced body mass index. These are regarded as important facets for long term control of blood pressure in communities (Clark et al., 2010; Fahey et al., 2005; Glynn et al., 2010; Hacihasanoglu and Gozum, 2011).

 

At present in India average population served per government allopathic doctor is 11,039.  Therefore nurses should be considered as intermediate strategy to manage non communicable diseases like HT using the task shifting policy to meet the human resource crisis. Nurses need to be adequately prepared for practicing the expanded roles. Such preparations must use evidence based strategies that provide nurses the opportunity to reflect on their own practices.

Hypertension control among elderly in India can be achieved by better government policies, political focus and social determinants of health such as education, development health system, proper health care financing, free or low-cost BP medicines, education for health care providers, free primary care, use of innovation in technology, collaboration with various stakeholders and patient empowerment.

Wala Awad & Anas AbuZaitoun

An Najah National University, Palestine

Title: ECGML- Electrocardiography using machine learning

Time : 11:15-12:15

Speaker
Biography:

Anas AbuZaitoun and Wala Awad are both computer engineering students at An-Najah National University. They will be graduating in less than 2 years, and they have a great interest in new technologies and machine learning in particular. Anas AbuZaitoun is not the typical type of students, he has been the organizer of GDG – Nablus branch for two years so far, and he is an active IEEE member. He is an Android developer, and he worked on many projects before, including mobile apps and desktop apps. He also attended Google’s I/O festival in San Jose this year. Wala Awad is an active member in both GDG and IEEE, and she is an Android developer as well. She is willing to get her master’s degree on machine learning as soon as she graduates. They have been participating in technical competitions that will employ both hardware and software.

 

 

Abstract:

Electrocardiography has been used extensively in diagnoses in almost all healthcare facilities. Upgrading this tool will reform diagnosis, and is expected to improve diagnosis and patient care. Thus, this project was designed to maximize potential benefits gained when machine learning technology is incorporated into ECG analysis. ECGML- electrocardiography using machine learning is a project created to enhance the performance of the typical ECG scanner by widening the area of its results and improving its accuracy. Using this technology, ECG can be used to not only show basic information about the heart but also to help diagnosing more than fifteen other arrhythmias precisely. Machine learning and Google’s Tensorflow were used to create a program that - when trained enough- will be able to diagnose those arrhythmias in the most accurate way possible. It is an easier and a faster way to be used in this field rather than the typical way.

 

Yochai Birnbaum

Baylor College of Medicine, USA

Title: Interpretation of ECGs of patients with pacemakers and ICDs

Time : 12:15- 12:40

Speaker
Biography:

Yochai Birnbaum has completed his MD from the Hebrew University of Jerusalem, Israel. He is the John S Dunn Chair, Professor of Medicine at Baylor College of Medicine, Houston, Texas, USA. He has published more than 320 papers in reputed journals and has been serving as an Editorial Board Member of six journals.

 

 

Abstract:

Clinicians rely more and more on the computerized interpretation of the 12-lead electrocardiogram (ECG). However, the current computerized algorithms are deficient for interpretation of ECGs of patients with implantable devices such as permanent pacemakers and defibrillators. Misinterpretation of the ECGs could lead to significant delays in recognizing device malfunction or underlying serious medical conditions, including arrhythmia. Systematic approach that includes understanding the basic principles of ECG interpretation, the common timings and algorithms of the devices can improve ECG interpretation and patient care. One common problem is missing underlying atrial fibrillation of flutter. As the heart rate of patients with underlying atrial flutter can be regular in patients with pacemaker, missing this diagnosis on ECG interpretation can lead to significant delay in initiation of anti-coagulation therapy for prevention of stroke. In the presentation we will show a series of ECGs of patients with devices and discuss the approach to interpretation.

 

 

Grace M. Egeland

Norwegian Institute of Public Health & University of Bergen, Norway

Title: One year prognosis of unspecified chest pain

Time : 12:40-13:05

Speaker
Biography:

Prof. Egeland holds a Ph.D. in Chronic Disease Epidemiology from the University of Pittsburgh, Pennsylvania with considerable expertise in epidemiological methods and analyses of complex data in cross-disciplinary research involving cardio-metabolic diseases, reproduction, and nutritional health. She currently works as Senior Researcher at the Norwegian Institute of Public Health and is Adjunct Professor at the Dept. of Global Public Health and Primary Care, University of Bergen, Norway.  She has over 135 publications including book chapters; is currently engaged in registry-based research, and leads several research projects spanning disciplines in life-course epidemiology. 

 

Abstract:

Prognosis of unspecified chest pain is important given the high frequency of chest pain leading to emergency medical care. The 1-yr prognosis of patients (aged 20-89 years) discharged with a primary diagnosis of unspecified chest pain (ICD-10, R072-R074) in 2010-2012 was evaluated using Norwegian health care administrative data sources.  For evaluation of incident events, patients with a prior 2-yr history of chest pain or cardiovascular disease (CVD) were excluded.  Nelson-Aalen cumulative hazards of incident ischemic heart disease (IHD) and monthly hazards of mortality following discharge were evaluated. Mortality was also compared to the general population by standard mortality ratios (SMR). There were 59,569 patients identified; the majorities were referred to hospital or outpatient clinics by community emergency medical centers. The hazards of mortality and the percent of deaths attributed to cardiovascular disease (CVD) were highest within the first 2 months post discharge.  Cumulative hazards of IHD for men aged 45-64 and 65-74 years was 12% and 20%, and for women 6% and 10%, respectively by age group.  Men and women under 65 yrs. of age had significantly higher non-CVD mortality than expected: SMR (95% CI) for men > 65 yrs. of age was 1.35 (1.2-1.6); for men < 65 yrs. of age was 1.53 (1.21-1.91); and for women < 65 yrs. of age the SMR was 1.54 (1.17-1.98). The prognostic data indicates that patients discharged with unspecified chest pain are an at-risk group in terms of early post-discharge mortality, incident IHD, and non-CVD mortality.

 

 

Le Fang

Zhejiang Provincial Center for Disease Control and Prevention, China

Title: Cardiovascular risk predictors for population aged 50-74 in Zhejiang province, China

Time : 14:05- 14:30

Speaker
Biography:

Le Fang has received his PhD degree from Shandong University, School of Public Health in China. He is the Section Chief in Department of Non-communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, China. He has published more than 15 papers in the field of non-communicable disease epidemiology and mental health.

 

 

 

Abstract:

Risk factors for cardiovascular disease (CVD) may differ among different population and race. In order to explore the risk factors for CVD among the Chinese population, total 25640 residents aged 50-74 years from two cities in Zhejiang province, China were included in this study. The data of their health records and CVD surveillances during year 2012-2015 were used and logistic regression model were employed for risk factor prediction. CVD surveillance included both coronary heart disease and stroke. Totally, 20534 cases were used for training sample and 5106 cases for test sample. The median time for following is two and a half years. By the end of the following, 742 cases had CVD event. The results showed that gender, age, diabetes, smoking, systolic pressure, total cholesterol (TC), high density lipoprotein (HDL) were predictors for CVD among Chinese population.

Speaker
Biography:

Laura Azevedo is a brazilian infectious diseases physician, completed her MSc of Public Health in Developing Countries at LSHTM and has recently started a PhD of economic evaluation of health interventions at University of São Paulo.  She works as medical coordinator in an emergency care unit and as data analysis supporter for the regional health care network. There, she works for SPDM, a health organization responsible for the management of all health care units of this district in the outskirts of the biggest city in Brazil - São Paulo.

 

Abstract:

The line of care (LC) is defined as a set of knowledge and resources those are needed to cope with specific conditions in the life cycle. The hypertension has a specific LC, named HLC and the great challenge consists on the reduction of the cardiovascular risk classification of the patients. This study was done to demonstrate the efficiency of the HLC. A cross-sectional descriptive study was performed in a Brazilian basic health care unit. The data were collected between January and October of 2017. The sample was composed of 28 users those were hypertension carriers, having an inclusion criteria for the registration in the HLC in January 2017 and has a ‘very high additional risk’ classification on the occasion of its inclusion in the HLC. The results showed a progressive decrease in cardiovascular risk. There was a reduction of 82.15% (N=23) of the ‘very high additional risk’ ratings. It is inferred that the reduction was not greater due to the risks that could not be controlled or excluded from the classification metrics like prior cardiovascular events and acute myocardial infarction. These users were downgraded to high risk 53.57% (N=15) and moderated risk 28.57% (N=8). It is observed a greater adhesion of the patients to the medical and nursing consultations, educational group of the HLC and to the Singular Therapeutic Project. It is concluded that the HLC is effective in reducing the very high cardiovascular additional risk classification of the follow-up users, contributing significantly to the reduction of morbimortality in hypertension users.

 

 

Speaker
Biography:

Marcello Finardi Peixoto obtained his medicine degree from Federal University of Sao Paulo Medical School. His Residency training was in Psychiatry at Santa Casa of Sao Paulo. He received a Master of Science degree in Nephrology from Federal University of Sao Paulo Medical School, where he also did a specialization in Psychopharmacology. He joined a Scientific Initiation Program during his Medical training when he published his first two original articles. He has been practicing since 2003 in his own private practice center. His current interests include mental disorders, particularly mood and anxiety disorders and its relation to general medical diseases.

 

 

Abstract:

Objective: The objective of the study was to test the role of escitalopram on blood pressure and heart rate of individuals with hypertension and depression.

Methods: A total of 30 individuals participated in this study and the individuals were being treated for hypertension and were diagnosed with major depression. Escitalopram (10-20 mg) was administered to 15 individuals, while the other 15 received placebo. These individuals were followed for eight weeks with regular monitoring of blood pressure and heart rate. Scores on the Hamilton Depression Rating Scale were evaluated within the first, second, fourth and eighth weeks of the study onset.

Results: Comparing with placebo, heart rate was lower in the escitalopram group (66.79±9.85 vs. 74.10±9.52 bpm, p=0.044). There was not a significant decrease of systolic blood pressure (140.80±16.48 vs. 139.61±18.92 mmHg, p=0.85) and diastolic blood pressure (80.55±12.64 vs. 80.18±16.36 mmHg, p=0.94).

Conclusion: Escitalopram decreases heart rate but not blood pressure in individuals with hypertension and depression.

 

Ersin Akpinar

Prof. of Clinical Family Medicine, Cukurova University, Adana - Turkey

Title: The trendy word of the year is "New”: 2018 Arterial Hypertension Guidelines
Speaker
Biography:

Prof. Dr. Ersin AKPINAR completed his specialty training in family medicine at Adana Numune Research and Training Hospital. He started working at Cukurova University Medical Faculty Departmeny of Family Medicine in January 2000 and was appointed as a full clinical professor of family medicine in 2013. He studied at The Universite Libre de Bruxelles in Brussels between 2004-2005 at the Department of Family Medicine, at the University of Illinois at Chicago in 2005, The United States Department of Medical Education for a period of two months fellowship in Clinical Decision Making fellowship, in Akademisches Lehrkrankenhaus der Universität Duisburg-Essen Sankt Clemens Hospitale Sterkrade in 2010, Germany for the project of The Research and residency education needs for improving the quality of gastrointestinal diseases care in family medicine and at the University of Michigan Department of Learning Health Science in United States at 2014 for a period of three months fellowship in Relevance and usability of high technologic patient simulators for clinical decision making and better clinical skills in undergraduate medical education curriculum fellowship. The main areas of interest in primary care of acute and chronic diseases, hypertension, cardiovascular risk analysis, sexuality, and sexual dysfunctions, medical education, learning models, the electronic patient record programs, social media, digital health and innovation. He still works on many university-funded research projects.

 

Abstract:

Sustained high blood pressure (BP) is a leading risk factor for developing heart disease, stroke, and renal disease. Globally, over 1 billion people have hypertension. As populations age and adopt more sedentary lifestyles, the worldwide prevalence of hypertension will continue to rise towards 1.5 billion by 2025. The positive association between BP and cardiovascular disease (CVD) risk has been well established. Classification of BP levels into categories supports clinical decision making, public health surveillance, and public and private programmatic activities.

As substantial progress has been made in understanding the epidemiology, pathophysiology, and risk associated with hypertension, and a wealth of evidence exists to demonstrate that lowering blood pressure (BP) can substantially reduce premature morbidity and mortality, a great number of guidelines have been issued in recent years by the European Society of Cardiology (ESC) and by the European Society of Hypertension (ESH), as well as by other societies and organisations. Because of the impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the users in 2018 The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) Guidelines for the management of arterial hypertension.

A number of proven, highly effective, and well-tolerated lifestyle and drug treatment strategies can achieve this reduction in BP. Despite this, BP control rates remain poor worldwide and are far from satisfactory across Europe. Consequently, hypertension remains the major preventable cause of CVD and all-cause death globally and in our continent

What is new and what has changed in New 2018 Arterial Hypertension Guidelines? will be the main theme of this session.