Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 6th World Congress on Hypertension and Public Health Paris, France.

Day 1 :

Keynote Forum

Ehud Baron

Chairman, President/CTO in Medical device companies: X-Cardio, Tokyo, GoldTech Sino, HK, Concardio, Inc., Cleveland and HeartBeat Technologies, Israel, and JV with LifeQ, SA, US, NL

Keynote: While you were sleeping- night cardiology health maps

Time : 09:55

Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Ehud Baron photo
Biography:

Ehud Baron MD D.Sc, Ex-prof. and researcher in Technion – Israel Inst. Of Technology, Aalborg University, UC Berkeley and Stanford University. Serial entrepreneur that serves as Chairman, President/CTO in Medical device companies: X-Cardio Corp. KK, Tokyo, GoldTech Sino, HK, Concardio, Inc., Cleveland and HeartBeat Technologies, Ltd., Israel, and JV with LifeQ, SA, US, NL.

Abstract:

The Problem: In order to appreciate the meaning of Hypertension beyond BP numeric value, we can employ 24H unobtrusive monitoring of cardiovascular health to assess progress or deterioration, and produce 24H BP graphs and Personal Health Maps (PHM)

 

Methodology: We suggest PHM for each patient to provide at a glance the position of the patient on the Health Space at any given time. It is based on Fuzzy sets, where each patient get different level of membership in different pathological and healthy conditions. The PHM shows the patient’s Pulse Shape trace during the night and condition can be assessed in one glance. In one study in Calcutta hospital, 30 hypertensive and diabetic patients were monitored at home 24H both with ABPM recording their BP every 15 min and continuous PPG that was used to predicted BP and Cardiac Output continuously. In a second clinical trial we compared our Hemodynamics prediction to Continuous Hemodynamics CNAP device, during Hemodialysis in Fresenius Kidney Center, in St. Louis hospital. Using 2-4 light wavelengths allowed us also to interrogate the capillary bed at different penetration levels to estimate features related to the microcirculation.

 

Findings: We did Fuzzy clustering by an algorithm we developed to cluster the pulse shapes in the feature space. We discovered that different health conditions fell into different clusters.

 

Conclusions & Significance: The finding that different health condition can be defined by the BP pulse shape clustering, generates a continuous Health space. Cluster centroids that represent various pulse shape belong to different health conditions. This provides a powerful tool to see patients progress or deterioration in a quantitative way that also indicates the way for more effective interventions. It is only the very beginning but first finding look quite promising. This can solve the problem of cardiology at night time, or how to detect deterioration in early stage in an unobtrusive and automatic way during night watch.

 

Keynote Forum

Sandeep Shah

CEO, Tarilian Laser Technologies and ViCardio & Senior Clinical Fellow, The Barts Heart Centre, London

Keynote: A Dynamic New World Order for Digital Blood Pressure Measurement: Introduction to Tarilian Laser Technologies

Time : 11:05 AM

Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Sandeep Shah photo
Biography:

Dr Sandeep Shah is a leading pioneer in the Medtech Industry and a Medical Doctor, an international Medical Technology Development Expert with sector expertise in technology transfer, regulation, clinical research, market adoption and business development. He is an expert on blood pressure measurement and haemodynamics. Sandeep is Co-Founder and CEO of Tarilian Laser Technologies and ViCardio® Ltd, which has developed an award-winning patented powerful cuffless non-invasive solution to blood pressure measurement and haemodynamics.

 

Abstract:

Tarilian Laser Technologies (TLT) is an innovative Medtech Company based in Welwyn Garden City, Hertfordshire & Leeds and also Minneapolis, Minnesota, USA. Our main clinical centre is The Barts Heart Centre in London, Europe’s largest cardiovascular research centre. At TLT, we have developed a novel optical platform technology based on our internal proprietary patented opto-electronic micro-sensor for full haemodynamic profiling including our ability to generate beat to beat blood pressure, compliance data, cardiac output and regional blood flow and blood pressure. A unique aspect of the TLT Sapphire sensor is that no energy enters the body at all – hence, it is truly non-invasive and does not require any compression/cuff and nor any calibration. The sensor is simply applied onto the body and it works instantly delivering continuous beat to beat haemodynamic data. The technology has already won many international awards and TLT has over 47 issued patents. TLT is finalizing its manufacturing translation programme for market launch. The TLT technology is set to revolutionize blood pressure measurement and cardiology, including in the community, hospital ward and OPD and critical care; and also, the emerging consumer wearable markets. An additional interest is the ability of our technology to measure regional/localized blood pressure and flow: including central retinal, renal arterial, maternal and fetal and placental blood pressure and flow. TLT has also commenced major programme of research on blood pressure variability and novel carotid applications especially in relation to the carotid body and sinus. The author will present the data from the pivotal study comparing the TLT technology performance to that of the intra-arterial line (IABP) at The Barts Heart Centre ICU.

 

 

Keynote Forum

Nita Shah

CTO, Co-Founder, Tarilian Laser Technologies( TLT ) and Vicardio ® Ltd.

Keynote: The future horizons for development of digital products for the cardiovascular sector and the impact of machine learning

Time : 11:50 AM

Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Nita Shah  photo
Biography:

Nita Shah is a global thought-leader and Inventor in the Medtech Industry, with significant Medtech Engineering expertise and also is a Molecular Biologist and Virologist. Nita is an expert on medical device engineering and product development. 
Nita is Co-Founder and CTO of Tarilian Laser Technologies and ViCardio® Ltd, which has developed an award-winning patented powerful cuffless non-invasive solution to blood pressure measurement and haemodynamics.
 

Abstract:

The author will describe the exciting new modern world of digital Medtech development – the future significance of digital products and their disruption of modern day cardiovascular medical and surgical management through novel sensing platforms. She will expand on future horizons in biometric sensing in cardiology– the opportunities, challenges and likely impacts on clinical care pathways. The author will also describe the journey of development of Tarilian Laser Technologies (TLT) – which is an innovative Medtech Company based in Welwyn Garden City, Hertfordshire and Leeds and also Minneapolis, Minnesota, USA; with its main clinical center being at The Barts Heart Centre in London, Europe’s largest cardiovascular research center. TLT have developed a novel optical platform technology based on its internal proprietary patented opto-electronic micro-sensor for full hemodynamic profiling including our ability to generate beat to beat blood pressure, compliance data, cardiac output and regional blood flow and blood pressure. She will also describe the modern world of rapid product development and prototyping, how to engage doctors, nurses and patients in product design and development, and how the industry is going through a new revolution through the impact of Artificial Intelligence Systems.

 

Keynote Forum

Rola Bou Serhal

Lebanese University, Lebanon

Keynote: A new Lebanese medication adherence scale: Validation in Lebanese hypertensive adults

Time : 14:00

Conference Series Euro Hypertension 2018 International Conference Keynote Speaker Rola Bou Serhal photo
Biography:

Rola Bou Serhal has completed her Research Master’s in Public Health, Epidemiology and Biostatistics branch from the Lebanese University. She holds a BS in Nursing from the Lebanese University too. She is a Clinical Research Assistant at the Clinical Research Center of Saint Joseph University (USJ). This is her first publication in a promising research career that she is building.

 

Abstract:

Background: Hypertension control reduces cardiovascular risk. Yet, lack of adherence to medication reduces this control. Therefore, tools to measure medication adherence are needed. A new Lebanese scale measuring medication adherence considered socioeconomic and cultural factors not taken into account by the eight-item Morisky Medication Adherence Scale (MMAS-8).

 

Objectives: The main objectives of this study were to validate the new adherence scale and its prediction of hypertension control, compared to MMAS-8, and to assess adherence rates and factors.

 

Methodology: A cross-sectional study, including 405 patients, was performed in outpatient cardiology clinics of three hospitals in Beirut. Blood pressure was measured, a questionnaire filled, and sodium intake was estimated by a urine test. Logistic regression defined predictors of hypertension control and adherence.

 

Results: A percentage of 54.9% had controlled hypertension and 82.4% were adherent by the new scale which showed good internal consistency, adequate questions (KMO coefficient = 0.743), and four factors. It predicted hypertension control (OR = 1.217; p value = 0.003), unlike MMAS-8, but the scores were correlated (ICC average measure = 0.651; p value < 0.001). Stress and smoking predicted non-adherence.

 

Conclusion: This study elaborated a validated, practical, and useful tool measuring adherence to medications in hypertensive patients.

 

  • Hypertension and Public Health | Blood Pressure Measurements | Effects of Hypertension in the population | Coronary Artery Disease | Cardiac Nursing | Cardiovascular Medical Devices
Location: Paris, France
Speaker

Chair

Sandeep Shah

Tarilian Laser Technologies and ViCardio & The Barts Heart Centre, UK

Speaker

Co-Chair

Grace M. Egeland

Norwegian Institute of Public Health & University of Bergen, Norway

Speaker
Biography:

Abstract:

Arterial Hypertension is an important cardiovascular risk factor. Patients on dialysis have an increase cardiovascular risk when compared with general population. The last  Brazilian census of Nephrology published in 2017 showed that arterial hypertension remains as the first cause of chronic kidney disease leading to dialysis in Brazil.

P.Medeiros el al analyzed 67 patients from a single center  and found that only 35,8% of patients on haemodialysis (HD) achievied the target blood pressure (BP), including here patients using at least one class of anti-hypertensive drug. In this study hypertension was definided as Systolic BP pre HD <140mmHg and Diastolic BP pre HD<90mmHg.

The CORDIAL study perfomed between 2010-2011 collected data from 1200 patients  and found a prevalence of hypertension of 87,4%. The definition of hypertension was the same as defined above plus the use of any anti-hypertensive drug.

There are still a lack of data about BP control in haemodialysis patients in Brazil but the data available show a high prevalence of hypertension on this population. Lowering blood pressure objecting blood pressure control should be pursue to reduce cardiovascular events and mortality in patients on dialysis.

 

Speaker
Biography:

Rola Bou Serhal has completed her Research Master’s in Public Health, Epidemiology and Biostatistics branch from the Lebanese University. She holds a BS in Nursing from the Lebanese University too. She is a Clinical Research Assistant at the Clinical Research Center of Saint Joseph University (USJ). This is her first publication in a promising research career that she is building.

 

 

Abstract:

Background: Hypertension control reduces cardiovascular risk. Yet, lack of adherence to medication reduces this control. Therefore, tools to measure medication adherence are needed. A new Lebanese scale measuring medication adherence considered socioeconomic and cultural factors not taken into account by the eight-item Morisky Medication Adherence Scale (MMAS-8).

 

Objectives: The main objectives of this study were to validate the new adherence scale and its prediction of hypertension control, compared to MMAS-8, and to assess adherence rates and factors.

 

Methodology: A cross-sectional study, including 405 patients, was performed in outpatient cardiology clinics of three hospitals in Beirut. Blood pressure was measured, a questionnaire filled, and sodium intake was estimated by a urine test. Logistic regression defined predictors of hypertension control and adherence.

 

Results: A percentage of 54.9% had controlled hypertension and 82.4% were adherent by the new scale which showed good internal consistency, adequate questions (KMO coefficient = 0.743), and four factors. It predicted hypertension control (OR = 1.217; p value = 0.003), unlike MMAS-8, but the scores were correlated (ICC average measure = 0.651; p value < 0.001). Stress and smoking predicted non-adherence.

 

Conclusion: This study elaborated a validated, practical, and useful tool measuring adherence to medications in hypertensive patients.

 

Speaker
Biography:

Laura Azevedo is a brazilian infectious diseases physician, completed her MSc of Public Health in Developing Countries at LSHTM and has recently started a PhD of economic evaluation of health interventions at University of São Paulo.  She works as medical coordinator in an emergency care unit and as data analysis supporter for the regional health care network. There, she works for SPDM, a health organization responsible for the management of all health care units of this district in the outskirts of the biggest city in Brazil - São Paulo.

 

 

Abstract:

The line of care for hypertensive and diabetics (LCHD) aims to be the guide of care in primary health care. Care systematization, cardiovascular risk classification and return flowchart require standards so that all the information is collected uniformly, whether in the reception, medical or nursing consultations or in attendance by the multiprofessional team.  The objective of this study was to present the forms of a LCHD. Experience report on the forms of a LCHD implemented in 2012 at the Vila Maria Vila Guilherme Health Network. The first version of the service form being capable of structuring the LCHD logic was developed in 2013. In 2015, it was revised and brought more objectivity maintaining the vital signs, anthropometric measurements, laboratory results, emergency or hospitalization care, diabetic foot evaluation and information on physical activities. In the same year, the need of sharing the management of care with the user, a singular therapeutic project form was developed, which symbolized a contract between the patient and the professional. At the end of 2017, in addition to contributing to the follow-up of the disease, ensure continuity of care and communication between the team, the return-on-consultation records stood out, since it was a priority to ensure compliance with the LCHD flowchart. More efficient attendances, more accurate monitoring of patients and to extract the characterization of the epidemiological profile are real contributions from LCHD's structured and constantly updated records. Although today, six years after its first version, difficulties in its fulfillment are found and these are essential for the execution of the LCHD.

 

 

Joao Brocas

Tarilian Laser Technologies Ltd (TLT), UK

Title: The wearable technology
Speaker
Biography:

Joao Brocas is a Wearable’s Expert and a globally recognized top 100 Global Digital Health Influencer. His passion lies in helping others, sharing experiences, transferring knowledge, working collaboratively and passing on the latest innovation trends from the digital health world as a Thought Leader in wearable’s, digital health, IoT and healthcare innovation, including AI (artificial intelligence), robotics and ML (machine learning). He has explored the intersection of technology in modeling business models and shaping consumer behavior. Also, he analyses the impact of disruptive innovations and shares future trends in the marketplace.

 

 

Abstract:

The world has reached an unprecedented point in new digital technology developments, where novel wearable technologies will now be able to revolutionize everyday management of chronic disease. Cardiovascular disease is the world’s single biggest killer. As such, this is an area significantly appropriate for the introduction of remote monitoring medical wearable technologies. Joao Brocas, a recognized expert in digital technology, will explain how the modern consumer wants to interact with this dynamic new world, as well as what challenges and opportunities lie ahead and why this is one of the world’s most exciting area for consumer engagement. Joao will also highlight the revolutionary manner in how TLT’s new digital platform technology and the revolutionary ViCardio product will drive the future of this sector.

 

Mafalda Castelão1

Mafalda Castelão is currently working in the Department of Pediatrics, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

Title: Adolescent obesity and associated hypertension: A red flag for the near future
Speaker
Biography:

Mafalda Castelão  is currently working in the Department of Pediatrics, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

 

Abstract:

Introduction: The world is in the grip of an obesity crisis, associated with a substantial increase in the prevalence of hypertension among youth. Obesity and elevated blood pressure (BP) in adolescents are both risk factors for cardiovascular disease that track into adulthood. New guidelines on pediatric hypertension were published that may change the previous diagnoses of hypertension.

 

Objective: The main objective of this study was to evaluate the prevalence of hypertension and the impact of the updated European guidelines on excess weight adolescents.

 

Methods: Retrospective cohort study (2011-2018) of overweight and obese adolescents, with BP measurements on at least three separate visits.

 

Results: Three hundred eleven (311) adolescents (48% male; 15.1±1.63 years old; BMI 32.2±5.85 kg/m2) were included. Hypertension was identified in 15% and 9% according to the 2009 and 2016 European Society of Hypertension (ESH) guidelines, respectively (p=.003). The prevalence of hypertension above the age of 16 was reduced by 76% (p<.001), mostly among males (p=.004). The estimates of high-normal BP decreased from 29% to 15% (p<.001), reclassifying as normotensive predominantly adolescents with a lower BMI (33.4±5.81 vs 35.7±7.22; p=.025). The overall prevalence of abnormal BP decreased by 45% (from 44% to 24%; p<.001), irrespective of gender, age or BMI.

 

Conclusions: The new ESH guidelines classified nearly half less adolescents with elevated BP and hypertension, with more than two thirds of the older adolescents reclassified as normotensive. Nevertheless, the prevalence of hypertension remained extremely high as compared to the healthy weight youth. Recognition of the premature beginning of cardiovascular disease among this at-risk population is a key public health target to reduce adult morbidity and mortality.

Speaker
Biography:

Laura Azevedo is a brazilian infectious diseases physician, completed her MSc of Public Health in Developing Countries at LSHTM and has recently started a PhD of economic evaluation of health interventions at University of São Paulo.  She works as medical coordinator in an emergency care unit and as data analysis supporter for the regional health care network. There, she works for SPDM, a health organization responsible for the management of all health care units of this district in the outskirts of the biggest city in Brazil - São Paulo.

 

 

Abstract:

The hypertension line of care (HLC) contemplates the continual care and interconnects to the hypertension carriers on the health care system. Therefore, it is essential that the technical team have adherence to the line. Thus, health care managers proposed the production of an educational video (EV) about HLC for the professionals. The theoretical reference for the production of the EV about the HLC was the format of Fleming, Reynolds and Wallace. The EV production took place in June 2018 in the Rede Assistencial de Saúde Vila Maria and Vila Guilherme with institutional resources and the acquisition of the video software VideoScribe®. In pre-production, the script was written by two specialists, one in education and another in public health. It was based on the story of a fictional character, 64 years old Dona Joana, who after moving from her home has a headache and seeks the health service, initiating the investigation of hypertension. It is narrated her attendance in the center of specialty, in the hospital and her return to the basic unit of origin that accompanies her continuously. An experienced nurse, a reference to HLC, analyzed the script. The video production and audio recording were done. In post-production the EV was released, with 4:11, on Youtube® (https://www.youtube.com/watch?v=ZwXV0RaY4mo) with the option of automatic subtitles on a variety of languages, counting 600 views since the publication. It is possible to make an EV with few resources and contribute in a simple and effective way with the qualification of the professionals for the integral care of the patients with hypertension.

 

Speaker
Biography:

Mawar Shashi has experience of 18 years in various positions, presently she is working as a Lecturer at college of Nursing, AIIMS New Delhi and a lifetime member of Trained Nurses Association of India, Nursing Research Society of India, Indian Association of Neonatal Nurses and Indian Association of Preventive and social medicine.

She participated as co-ordinator, Panelist, and Resource person at various National and International forums. She is a Master trainer for Global Funded project for Aids, Tuberculosis and Malaria- AIDS and Tuberculosis, Advanced trauma care for Nurses etc. She has some national and international publications and paper presentations.

 

Abstract:

Introduction: Hypertension exerts a substantial public health burden on cardiovascular health status and health care system in India. It has been estimated that among adults>50 years of age, the lifetime risk of developing hypertension approaches 90%. BP is frequently underdiagnosed and undertreated among elderly therefore a community based screening followed by a nurse-led BP control program was taken up.

Methods: A cross sectional survey was done to assess the prevalence of hypertension among 1386 elderly. Quasi experimental design was created to assess the effectiveness of nurse-led program on management of hypertension. Purposive sampling adopted to enroll 378 hypertensive patients. Study group and control group were divided on the basis of blocks. Community based nurse-led program is a holistic program covering life style modification, stress management, dietary modification, physical activity and medication adherence.

Results: Overall prevalence of hypertension was 34.6% with 31% among males and 36% among females. Mean age was 64.5 years. Both groups were homogenous with respect to all risk factors at baseline. There was a significant difference in SBP at 6 months p=0.04 (95%, CI: 0.04-4.01) and one year p<0.001 (95%, CI: 2.4-5.9) among study group subjects. Mean BP reduced by 6 mmHg at the end of one year among study group. Significant difference in total cholesterol, TGL and VLDL levels was also found. Mean reduction of 13.1 mg/dl in total cholesterol among study group p=0.003 (95%, CI: 2.3-11.6)

Conclusion: Community based nurse-led program is effective in managing BP.

Foroohar Foroozan

She holds Ph.D., PEng of Ontario, Canada, Systems and Signal Processing Engineer, Analog Devices Incorporation

Title: 24H unobtrusive blood pressure monitoring and health maps in treating hypertension
Speaker
Biography:

Foroohar Foroozan is system software and signal processing scientist at Analog Devices Inc. (ADI) leading the algorithm design for vital signs and in-home monitoring systems for the healthcare business unit in Toronto. The mission of this technology development group is to deliver the embedded platform, cloud, and analytics technologies required to meet the ADI IoT product and service ambitions. She is also collaborating with the Echo2Bits healthcare team for Point-of-Care ultrasound imaging systems. She was a postdoctoral fellow at Sunnybrook Research Institute working on 3D super-resolution ultrasound imaging for brain vascular mapping from 2012 to 2013 with a PCT patent pending. She was also a lecturer at the University of Ontario Institute of Technology, teaching both graduate courses from 2011 to 2012. She received her PhD degree in computer science from Lassonde School of Engineering, York University, Toronto, Canada in 2011. Her area of interest is in signal processing and algorithms in biomedical systems with focus on body area sensors for vital signs systems, in-home monitoring systems for assisted living and biomedical imaging. Dr. Foroozan’s work on compact ultrasound imaging system was awarded at the Sunnybrook-Schulich Innovation program in 2014, with a PCT patent. She is a member of the Professional Engineering Society of Ontario (PEng.) and a senior member of the IEEE.

 

 

 

Abstract:

 

Problem: Continuously monitoring the Blood Pressure (BP), specially for people of advanced age and those who are at a high risk of developing cardiac disease is very important. Currently, continuous BP measurements, including nocturnal, require surgical insertion of an intra-arterial monitor, only occurring in an ICU environment. Non-invasive BP measurements are limited to cumbersome products requiring deliberate inflation & producing only spot measurements, often negatively impacted erroneous procedures during measurement. Medical providers, patients and pharma need continuous, real life measurements without expensive, bulky invasive equipments.  In this work, 24H unobtrusive monitoring of cardiovascular health is implemented using wrist-based Photoplethysmography (PPG) signals, in which we produce 24H BP graphs and Personal Health Maps (PHM).

 

Methodology: We suggest PHM for each patient to provide at a glance the position of the patient in the Health Space 24H. The algorithm is based on Fuzzy clustering, where each patient is assigned with a different level of membership in different pathological and healthy conditions. The PHM shows the trace of a patient’s PPG pulse shape during day and night in one glance. In one study in Calcutta hospital, 30 hypertensive and diabetic patients were monitored at home 24H both with an Ambulatory Blood Pressure Monitoring (ABPM) device which records the BP every 15 min together with a continuous PPG  recordings in order to estimate the BP and Cardiac Output  (CO) continuously. In a second clinical trial, we compared our Hemodynamics prediction to that of a continuous Hemodynamics CNAP device, during Hemodialysis in Fresenius Kidney Center, in St. Louis hospital. Using 2-4 light wavelengths allowed us also to interrogate the capillary bed at different penetration levels to estimate features related to the microcirculation.

 

Findings: We implemented Fuzzy clustering algorithm to cluster the pulse shapes in the feature space. We discovered that different health conditions fell into different clusters and it changes during 24H.

 

Conclusions & Significance: We showed that different health conditions can be defined by the PPG pulse shape clustering, which also generates a continuous Health space. Cluster centroids that represent various pulse shapes belong to different health conditions. This provides a powerful tool to monitor progress or deterioration of a patient in a quantitative way. It is quite crucial for people suffering from hypertension to monitor their BP continuously and get timely medical intervention, so that serious cardiovascular complications shall be prevented. This method can also solve the problem of nocturnal cardiac monitoring at home.

 

Speaker
Biography:

Wafaa Abdel-Rehim works as assistant professor of biochemistry, Medical Research Institute, Alexandria University, Egypt. I have published more than 20 papers in reputed journals, including Journal of Cellular Biochemistry in 2017 and Biological Chemistry in 2016.  

 

Abstract:

Background: klotho is recognized as an anti-aging protein, protects the cardiovascular system through endothelium – derived NO. Klotho deficiency disturbs endothelial integrity, but the molecular mechanism is not fully clarified.

Objective: To observe the relationship between klotho protein and biochemical marker of oxidative stress, endothelial dysfunction and arterial aging in non-treated and ACEI-treated patients with essential hypertension (EH).

Subjects& Methods: 80 subjects with essential hypertension, divided into two groups the first didn’t receive any hypertensive treatment (n=40) while the other (n=40) received angiotensin converting enzyme inhibitors (ACEIs), and 20 age and sex matched controls were included in the study. Serum levels of nitric oxide (NO), malondialdehyde (MDA), vascular endothelial growth factor-A (VEGF-A) and klotho protein were measured. Carotid Intima- Media Thickening (IMT) were determined by ultrasonography for all participants.

Results: Mean values of MDA, VEGF-A and IMT revealed significant increment while those of NO and Klotho showed significant reduction in non-treated EH patients compared to controls. Mean levels of MDA, VEGF-A and IMT showed significant reduction while those of NO and Klotho exhibited significant elevation in ACEI- treated patients compared to corresponding values of non-treated ones. Significant negative correlation between serum MDA concentration and NO levels and positive correlation between klotho level and NO were observed in the present study. 

Conclusion: soluble klotho may become an important target in vascular medicine, mainly in situations where senescence and stress is responsible for accelerated vascular damage as in hypertension. The addition of exogenous klotho may prevent the oxidative stress that induces premature senescence.

 

  • Cardiovascular Diseases | Healthcare & Technologies | Cardiac Diagnostic Tests | Device Therapy | Clinical Cases In Cardiology | Hypertension & Cardiology | Cardiovascular Risk Assessment |
Location: Paris, France
Speaker

Chair

Ehud Baron

X-Cardio Corp. KK, Japan

Session Introduction

Shashi Mawar

All India Institute of Medical Sciences, India

Title: Home based management of Hypertension among elderly: Indian scenario

Time : 10:50-11:15

Speaker
Biography:

Shashi Mawar has total experience of 18 years in various positions. Presently she is working as a Lecturer at college of Nursing, AIIMS New Delhi. She is a lifetime member of Trained Nurses Association of India, Nursing Research Society of India, Indian Association of Neonatal Nurses and Indian Association of Preventive and social medicine. She participated as co-ordinator, Panelist, and Resource person at various National and International forums. She is a master trainer for Global Funded project for Aids, Tuberculosis and Malaria- AIDS and Tuberculosis, Advanced trauma care for Nurses etc. She has some national and international publications and paper presentations.

Abstract:

Numerous studies have identified effective evidence based strategies in the control of high blood pressure used by nurses. Good quality studies demonstrated that, use of treatment algorithms, nurse prescribing, community monitoring are effective evidence based strategies that significantly reduced both systolic and diastolic blood pressure (Clark et al., 2010; Denver et al., 2003; Kotseva et al., 2010).

Numerous studies demonstrated that nurses’ role in patient education significantly improved patients’ health lifestyle behaviors, medication adherence self-efficacy, and reduced body mass index. These are regarded as important facets for long term control of blood pressure in communities (Clark et al., 2010; Fahey et al., 2005; Glynn et al., 2010; Hacihasanoglu and Gozum, 2011).

 

At present in India average population served per government allopathic doctor is 11,039.  Therefore nurses should be considered as intermediate strategy to manage non communicable diseases like HT using the task shifting policy to meet the human resource crisis. Nurses need to be adequately prepared for practicing the expanded roles. Such preparations must use evidence based strategies that provide nurses the opportunity to reflect on their own practices.

Hypertension control among elderly in India can be achieved by better government policies, political focus and social determinants of health such as education, development health system, proper health care financing, free or low-cost BP medicines, education for health care providers, free primary care, use of innovation in technology, collaboration with various stakeholders and patient empowerment.

Wala Awad & Anas AbuZaitoun

An Najah National University, Palestine

Title: ECGML- Electrocardiography using machine learning

Time : 11:15-12:15

Speaker
Biography:

Anas AbuZaitoun and Wala Awad are both computer engineering students at An-Najah National University. They will be graduating in less than 2 years, and they have a great interest in new technologies and machine learning in particular. Anas AbuZaitoun is not the typical type of students, he has been the organizer of GDG – Nablus branch for two years so far, and he is an active IEEE member. He is an Android developer, and he worked on many projects before, including mobile apps and desktop apps. He also attended Google’s I/O festival in San Jose this year. Wala Awad is an active member in both GDG and IEEE, and she is an Android developer as well. She is willing to get her master’s degree on machine learning as soon as she graduates. They have been participating in technical competitions that will employ both hardware and software.

 

 

Abstract:

Electrocardiography has been used extensively in diagnoses in almost all healthcare facilities. Upgrading this tool will reform diagnosis, and is expected to improve diagnosis and patient care. Thus, this project was designed to maximize potential benefits gained when machine learning technology is incorporated into ECG analysis. ECGML- electrocardiography using machine learning is a project created to enhance the performance of the typical ECG scanner by widening the area of its results and improving its accuracy. Using this technology, ECG can be used to not only show basic information about the heart but also to help diagnosing more than fifteen other arrhythmias precisely. Machine learning and Google’s Tensorflow were used to create a program that - when trained enough- will be able to diagnose those arrhythmias in the most accurate way possible. It is an easier and a faster way to be used in this field rather than the typical way.

 

Yochai Birnbaum

Baylor College of Medicine, USA

Title: Interpretation of ECGs of patients with pacemakers and ICDs

Time : 12:15- 12:40

Speaker
Biography:

Yochai Birnbaum has completed his MD from the Hebrew University of Jerusalem, Israel. He is the John S Dunn Chair, Professor of Medicine at Baylor College of Medicine, Houston, Texas, USA. He has published more than 320 papers in reputed journals and has been serving as an Editorial Board Member of six journals.

 

 

Abstract:

Clinicians rely more and more on the computerized interpretation of the 12-lead electrocardiogram (ECG). However, the current computerized algorithms are deficient for interpretation of ECGs of patients with implantable devices such as permanent pacemakers and defibrillators. Misinterpretation of the ECGs could lead to significant delays in recognizing device malfunction or underlying serious medical conditions, including arrhythmia. Systematic approach that includes understanding the basic principles of ECG interpretation, the common timings and algorithms of the devices can improve ECG interpretation and patient care. One common problem is missing underlying atrial fibrillation of flutter. As the heart rate of patients with underlying atrial flutter can be regular in patients with pacemaker, missing this diagnosis on ECG interpretation can lead to significant delay in initiation of anti-coagulation therapy for prevention of stroke. In the presentation we will show a series of ECGs of patients with devices and discuss the approach to interpretation.

 

 

Grace M. Egeland

Norwegian Institute of Public Health & University of Bergen, Norway

Title: One year prognosis of unspecified chest pain

Time : 12:40-13:05

Speaker
Biography:

Prof. Egeland holds a Ph.D. in Chronic Disease Epidemiology from the University of Pittsburgh, Pennsylvania with considerable expertise in epidemiological methods and analyses of complex data in cross-disciplinary research involving cardio-metabolic diseases, reproduction, and nutritional health. She currently works as Senior Researcher at the Norwegian Institute of Public Health and is Adjunct Professor at the Dept. of Global Public Health and Primary Care, University of Bergen, Norway.  She has over 135 publications including book chapters; is currently engaged in registry-based research, and leads several research projects spanning disciplines in life-course epidemiology. 

 

Abstract:

Prognosis of unspecified chest pain is important given the high frequency of chest pain leading to emergency medical care. The 1-yr prognosis of patients (aged 20-89 years) discharged with a primary diagnosis of unspecified chest pain (ICD-10, R072-R074) in 2010-2012 was evaluated using Norwegian health care administrative data sources.  For evaluation of incident events, patients with a prior 2-yr history of chest pain or cardiovascular disease (CVD) were excluded.  Nelson-Aalen cumulative hazards of incident ischemic heart disease (IHD) and monthly hazards of mortality following discharge were evaluated. Mortality was also compared to the general population by standard mortality ratios (SMR). There were 59,569 patients identified; the majorities were referred to hospital or outpatient clinics by community emergency medical centers. The hazards of mortality and the percent of deaths attributed to cardiovascular disease (CVD) were highest within the first 2 months post discharge.  Cumulative hazards of IHD for men aged 45-64 and 65-74 years was 12% and 20%, and for women 6% and 10%, respectively by age group.  Men and women under 65 yrs. of age had significantly higher non-CVD mortality than expected: SMR (95% CI) for men > 65 yrs. of age was 1.35 (1.2-1.6); for men < 65 yrs. of age was 1.53 (1.21-1.91); and for women < 65 yrs. of age the SMR was 1.54 (1.17-1.98). The prognostic data indicates that patients discharged with unspecified chest pain are an at-risk group in terms of early post-discharge mortality, incident IHD, and non-CVD mortality.

 

 

Le Fang

Zhejiang Provincial Center for Disease Control and Prevention, China

Title: Cardiovascular risk predictors for population aged 50-74 in Zhejiang province, China

Time : 14:05- 14:30

Speaker
Biography:

Le Fang has received his PhD degree from Shandong University, School of Public Health in China. He is the Section Chief in Department of Non-communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, China. He has published more than 15 papers in the field of non-communicable disease epidemiology and mental health.

 

 

 

Abstract:

Risk factors for cardiovascular disease (CVD) may differ among different population and race. In order to explore the risk factors for CVD among the Chinese population, total 25640 residents aged 50-74 years from two cities in Zhejiang province, China were included in this study. The data of their health records and CVD surveillances during year 2012-2015 were used and logistic regression model were employed for risk factor prediction. CVD surveillance included both coronary heart disease and stroke. Totally, 20534 cases were used for training sample and 5106 cases for test sample. The median time for following is two and a half years. By the end of the following, 742 cases had CVD event. The results showed that gender, age, diabetes, smoking, systolic pressure, total cholesterol (TC), high density lipoprotein (HDL) were predictors for CVD among Chinese population.

Speaker
Biography:

Laura Azevedo is a brazilian infectious diseases physician, completed her MSc of Public Health in Developing Countries at LSHTM and has recently started a PhD of economic evaluation of health interventions at University of São Paulo.  She works as medical coordinator in an emergency care unit and as data analysis supporter for the regional health care network. There, she works for SPDM, a health organization responsible for the management of all health care units of this district in the outskirts of the biggest city in Brazil - São Paulo.

 

Abstract:

The line of care (LC) is defined as a set of knowledge and resources those are needed to cope with specific conditions in the life cycle. The hypertension has a specific LC, named HLC and the great challenge consists on the reduction of the cardiovascular risk classification of the patients. This study was done to demonstrate the efficiency of the HLC. A cross-sectional descriptive study was performed in a Brazilian basic health care unit. The data were collected between January and October of 2017. The sample was composed of 28 users those were hypertension carriers, having an inclusion criteria for the registration in the HLC in January 2017 and has a ‘very high additional risk’ classification on the occasion of its inclusion in the HLC. The results showed a progressive decrease in cardiovascular risk. There was a reduction of 82.15% (N=23) of the ‘very high additional risk’ ratings. It is inferred that the reduction was not greater due to the risks that could not be controlled or excluded from the classification metrics like prior cardiovascular events and acute myocardial infarction. These users were downgraded to high risk 53.57% (N=15) and moderated risk 28.57% (N=8). It is observed a greater adhesion of the patients to the medical and nursing consultations, educational group of the HLC and to the Singular Therapeutic Project. It is concluded that the HLC is effective in reducing the very high cardiovascular additional risk classification of the follow-up users, contributing significantly to the reduction of morbimortality in hypertension users.

 

 

Speaker
Biography:

Marcello Finardi Peixoto obtained his medicine degree from Federal University of Sao Paulo Medical School. His Residency training was in Psychiatry at Santa Casa of Sao Paulo. He received a Master of Science degree in Nephrology from Federal University of Sao Paulo Medical School, where he also did a specialization in Psychopharmacology. He joined a Scientific Initiation Program during his Medical training when he published his first two original articles. He has been practicing since 2003 in his own private practice center. His current interests include mental disorders, particularly mood and anxiety disorders and its relation to general medical diseases.

 

 

Abstract:

Objective: The objective of the study was to test the role of escitalopram on blood pressure and heart rate of individuals with hypertension and depression.

Methods: A total of 30 individuals participated in this study and the individuals were being treated for hypertension and were diagnosed with major depression. Escitalopram (10-20 mg) was administered to 15 individuals, while the other 15 received placebo. These individuals were followed for eight weeks with regular monitoring of blood pressure and heart rate. Scores on the Hamilton Depression Rating Scale were evaluated within the first, second, fourth and eighth weeks of the study onset.

Results: Comparing with placebo, heart rate was lower in the escitalopram group (66.79±9.85 vs. 74.10±9.52 bpm, p=0.044). There was not a significant decrease of systolic blood pressure (140.80±16.48 vs. 139.61±18.92 mmHg, p=0.85) and diastolic blood pressure (80.55±12.64 vs. 80.18±16.36 mmHg, p=0.94).

Conclusion: Escitalopram decreases heart rate but not blood pressure in individuals with hypertension and depression.

 

Ersin Akpinar

Prof. of Clinical Family Medicine, Cukurova University, Adana - Turkey

Title: The trendy word of the year is "New”: 2018 Arterial Hypertension Guidelines
Speaker
Biography:

Prof. Dr. Ersin AKPINAR completed his specialty training in family medicine at Adana Numune Research and Training Hospital. He started working at Cukurova University Medical Faculty Departmeny of Family Medicine in January 2000 and was appointed as a full clinical professor of family medicine in 2013. He studied at The Universite Libre de Bruxelles in Brussels between 2004-2005 at the Department of Family Medicine, at the University of Illinois at Chicago in 2005, The United States Department of Medical Education for a period of two months fellowship in Clinical Decision Making fellowship, in Akademisches Lehrkrankenhaus der Universität Duisburg-Essen Sankt Clemens Hospitale Sterkrade in 2010, Germany for the project of The Research and residency education needs for improving the quality of gastrointestinal diseases care in family medicine and at the University of Michigan Department of Learning Health Science in United States at 2014 for a period of three months fellowship in Relevance and usability of high technologic patient simulators for clinical decision making and better clinical skills in undergraduate medical education curriculum fellowship. The main areas of interest in primary care of acute and chronic diseases, hypertension, cardiovascular risk analysis, sexuality, and sexual dysfunctions, medical education, learning models, the electronic patient record programs, social media, digital health and innovation. He still works on many university-funded research projects.

 

Abstract:

Sustained high blood pressure (BP) is a leading risk factor for developing heart disease, stroke, and renal disease. Globally, over 1 billion people have hypertension. As populations age and adopt more sedentary lifestyles, the worldwide prevalence of hypertension will continue to rise towards 1.5 billion by 2025. The positive association between BP and cardiovascular disease (CVD) risk has been well established. Classification of BP levels into categories supports clinical decision making, public health surveillance, and public and private programmatic activities.

As substantial progress has been made in understanding the epidemiology, pathophysiology, and risk associated with hypertension, and a wealth of evidence exists to demonstrate that lowering blood pressure (BP) can substantially reduce premature morbidity and mortality, a great number of guidelines have been issued in recent years by the European Society of Cardiology (ESC) and by the European Society of Hypertension (ESH), as well as by other societies and organisations. Because of the impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the users in 2018 The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) Guidelines for the management of arterial hypertension.

A number of proven, highly effective, and well-tolerated lifestyle and drug treatment strategies can achieve this reduction in BP. Despite this, BP control rates remain poor worldwide and are far from satisfactory across Europe. Consequently, hypertension remains the major preventable cause of CVD and all-cause death globally and in our continent

What is new and what has changed in New 2018 Arterial Hypertension Guidelines? will be the main theme of this session.